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ORIGINAL ARTICLE
Year : 2017  |  Volume : 4  |  Issue : 4  |  Page : 101-103

Comparative evaluation of alkaline phosphatase levels in dental pulp of diabetic and nondiabetic individuals


Department of Conservative and Endodontic Dentistry, Dr. D Y Patil Vidyapeeth, Dr. D Y Patil Dental College and Hospital, Pune, Maharashtra, India

Correspondence Address:
Dr. Pradeep Shetty
Department of Conservative and Endodontic Dentistry, Dr. D Y Patil Vidyapeeth, Dr. D Y Patil Dental College and Hospital, Pimpri, Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrr.jdrr_2_18

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Objective: The objective of this study was to evaluate changes in inflammatory components of alkaline phosphatase in dental pulp of patients with Type II diabetes mellitus and nondiabetic patients. Methodology: The study was carried out among 135 participants of the age group between 45 and 65 years, and participants were divided into three groups (n = 45 in each group) – a control group, diabetic with good glycemic control, and diabetic with poor glycemic contro l. After clinical examination with Russell's Periodontal Index, teeth indicated for extraction were extracted, and dental pulp was extirpated. Levels of alkaline phosphatase were assessed by p-nitro-phenylphosphate-2-amino-2-methyl-1-propanol (IFCC) and kinetic assay method. Results: Mean levels of the inflammatory component of alkaline phosphatase level were more in poorly controlled glycemic level group as compared to other two groups, and the difference between the groups was statistically significant (P < 0.001). Conclusion: Inflammatory mediators may have an impact on the pulpal treatment procedures. The results imply that diabetes is a critical factor that has profound effects upon oral tissues, resulting in expression of inflammatory mediators and modifications of structural components of dental pulp.


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