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DPU: INTERDISCIPLINARY CONFERENCE
Year : 2020  |  Volume : 7  |  Issue : 5  |  Page : 91-94

Role of praval bhasma in inducing osteogenic potential in human dental pulp stem cells


1 Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India
2 Department of Rasashastra and Bhaishajya Kalpana, Dr. D. Y. Patil Vidyapeeth, Pune, Maharashtra, India
3 Director (Research), Dr D Y Patil Vidyapeeth, Pune, Maharashtra, India
4 Dental Consultant, Pune, Maharashtra, India

Correspondence Address:
Uday Suresh Londhe
Department of Oral and Maxillofacial Surgery, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune-18, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrr.jdrr_74_19

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Background: The repair and regeneration of bone is a major issue in the oral and maxillofacial surgery and for the whole human body in general. Bone defects may result from trauma, oncologic surgeries, acute or chronic infections, and congenital malformations. Stem cells are natural and direct source from which stable differentiated cells are generated which lead to tissue formation. Mesenchymal stem cells exhibit the potential to differentiate into a variety of cells such as osteoblasts, myoblasts, chondrocytes, and adipocytes when subjected to various preconditioning agents. Praval Bhasma has never been tested as a preconditioning agent in human dental pulp stem cells (hDPSCs). Materials and Methods: Pulp was extirpated from the teeth of patients who fit in the selection criteria. HDPSCs were then isolated, characterized, and differentiated. Praval Bhasma was used as a preconditioning agent to replace each ingredient in standard osteogenic cocktail and individually to induce osteogenic potential in hDPSCs. Results: Praval Bhasma-induced osteogenic differentiation in hDPSCs when used to replace an ingredient in standard osteogenic cocktail and also when used individually. Conclusion: The use of Praval Bhasma may prove to be a better preconditioning agent for bone formation in hDPSCs.


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