• Users Online: 252
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2018  |  Volume : 5  |  Issue : 2  |  Page : 35-41

Candida species detection in potentially malignant and malignant disorders of the oral mucosa: A meta-analysis


Department of Oral Medicine. Faculty of Dentistry, University of Granada, Granada, Spain

Correspondence Address:
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jdrr.jdrr_27_18

Rights and Permissions

Background: Candida species, mainly Candida albicans, have been related to dysplastic changes and malignant transformation of different oral mucosal lesions. Objective: The objective was to assess the possible influence of Candida detection in oral leukoplakia (OL), oral lichen planus (OLP), and oral cancerous lesions. Search Methods: A PubMed search through February 2018, using the following MESH terms, was performed: “Candida,” “precancerous conditions,” “mouth,” and “mouth neoplasms.” Selection Criteria: The selection criteria included studies with findings on Candida detection in premalignant and malignant oral lesions. Data Collection and Analysis: For continuous outcomes, the estimates of effects of an intervention were expressed as mean differences using the inverse variance method and for dichotomous outcomes, the estimates of effects of an intervention were expressed as odds ratios using Haenszel—Mantel method, both with 95% confidence intervals. Results: Fifteen studies on Candida detection in premalignant and malignant oral lesions were included in this meta-analysis. Nearly 61.5% of oral cancers, 32.2% of OLs, and 29.1% of OLP lesions were infected by Candida species. Candida infection does not increase the risk for developing OL (P = 0.32) or OLP (P = 0.31). A higher mean age, male gender, tobacco consumption, and location of the lesions on tongue or floor of the mouth were factors that did not have a significant influence on developing Candida-infected OL. Dysplastic OLs were 10.62 times more likely to be Candida-infected lesions. A greater number of OL lesions infected by Candida species than OLP lesions were found (P < 0.01). Having oral cancer increased 4.92-fold risk of Candida infection. No statistically significant association between Candida-infected oral cancer lesions and Candida-infected OL lesions was observed (P = 0.21). Conclusions: Candida infection worsens the biological behavior of potentially malignant and malignant lesions of the oral cavity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed687    
    Printed54    
    Emailed0    
    PDF Downloaded195    
    Comments [Add]    

Recommend this journal