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ORIGINAL ARTICLE
Year : 2016  |  Volume : 3  |  Issue : 4  |  Page : 117-123

Assessing the effect of pomegranate fruit seed extract mouthwash on dental plaque and gingival inflammation


1 Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran
2 Department of Pharmacology and Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3 Students' Research Committee, School of Dentistry, International Branch, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Farin Kiany
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2348-2915.200016

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Background: Utilizing natural products in the prevention and treatment of periodontal diseases has been increased recently and could be of benefit to low-socioeconomic level communities. Mouthwashes are very useful in the reduction of microbial plaque and gingival inflammation. Pomegranate (Punica granatum ) is an essential medicinal plant with various pharmacological properties. In this study, the efficacy of a mouthwash prepared from the extract of pomegranate fresh fruit, was evaluated in the reduction of dental plaque and gingival bleeding. Materials and Methods: One hundred and four participants diagnosed as mild to moderate gingivitis participated in this double-blind clinical trial. Two weeks after thorough scaling and root planing, the participants were randomly and equally divided into four groups: group 1 - Persica, Group 2 - Matrica, Group 3 - pomegranate mouthwashes, and Group 4 - placebo. The participants were instructed to use the prescribed mouthwashes, twice daily, for 1 month. Pomegranate mouthwash was prepared from seeds of fresh pomegranate fruit. Periodontal parameters including plaque and bleeding indices were assessed at baseline (2 weeks after Phase I of treatment) and 1 month after using mouthwashes. Results: Comparison of the plaque index showed a significant reduction from baseline to 1 month in all groups (P < 0.05). However, there was no significant difference in reduction of plaque when comparing four groups. Assessment of the bleeding on probing revealed a significant decrease from baseline to 1 month in all groups (P < 0.05). The three herbal mouthwashes reduced the bleeding index significantly more than the placebo (P < 0.05). Conclusion: Pomegranate mouthwash was beneficial in improving gingival status, including reducing plaque and bleeding indices. Its effect was comparable to two routinely used herbal mouthwashes.


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